Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.

Journal of virological methods - 1 Jun 2013

Bhattacharya Debika, Lewis Martha J, Lassmann Britta, Phan Tina, Knecht Gaby, Bickel Marcus, Yang Otto O

Abstract excerpt

Detection of minor variant viral quasispecies of the rtV173L+rtL180M+rtM204V combination mutation in the hepatitis B virus (HBV) polymerase mediating both lamivudine resistance and vaccine escape is potentially important for tracking the development and evolution of resistance within both individuals and populations. A highly sensitive and specific assay to quantitate HBV genomes was developed with this mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Immune Evasion

Share to Lamivudine

Share to Molecular Diagnostic Techniques

Share to Oligonucleotide Probes

Source

Open in PubMed Open full text

Identifiers

PMID: 23454647
DOI: 10.1016/j.jviromet.2013.02.009
PMCID: PMC3861565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.PMID 23454647Read ↗

Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groove binder probe and peptide nucleic acids.Semantic proximity Read ↗

Real-time PCR detection of multiple lamivudine-resistant mutations with displacing probes in a single tube.Semantic proximity Read ↗

Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates.Semantic proximity Read ↗

A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations.Semantic proximity Read ↗

Fast and Sensitive Real-Time PCR Detection of Major Antiviral-Drug Resistance Mutations in Chronic Hepatitis B Patients by Use of a Predesigned Panel of Locked-Nucleic-Acid TaqMan Probes.Semantic proximity Read ↗

Quantification of lamivudine-resistant hepatitis B virus mutants by type-specific TaqMan minor groove binder probe assay in patients with chronic hepatitis B.Semantic proximity Read ↗

Two Sensitive PCR-Based Methods for Detection of Hepatitis B Virus Variants Associated with Reduced Susceptibility to LamivudineSemantic proximity Read ↗

Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.Semantic proximity Read ↗

Multiplex locked nucleic acid probes for analysis of hepatitis B virus mutants using real-time PCR.Semantic proximity Read ↗

Rapid quantitation of lamivudine-resistant mutants in lamivudine treated and untreated patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.Semantic proximity Read ↗

Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.