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Article

Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.

Journal of hepatology - 1 Jun 2004

Punia Parvinder, Cane Patricia, Teo Chong-Gee, Saunders Nicholas

Abstract excerpt

BACKGROUND/AIMS: Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of the HBV polymerase gene. We describe a method to detect and quantify mutant viral populations...

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Source

Identifiers

PMID: 15158340
DOI: 10.1016/j.jhep.2004.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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