Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groove binder probe and peptide nucleic acids.

Journal of clinical microbiology - 1 Dec 2010

Hige Shuhei, Yamamoto Yoichi, Yoshida Shigeru, Kobayashi Tomoe, Horimoto Hiromasa, Yamamoto Keiko, Sho Takuya, Natsuizaka Mitsuteru, Nakanishi Mitsuru, Chuma Makoto, Asaka Masahiro

Abstract excerpt

Lamivudine is the first nucleoside analogue that was shown to have a potent effect on hepatitis B virus (HBV). However, the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem. Several assays for the detection and quantification of antiviral-resistant mutants have been reported, but it has been difficult to measure the amounts of mutants accurately,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Hepatitis B virus

Share to Lamivudine

Share to Oligonucleotide Probes

Share to Peptide Nucleic Acids

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 20926703
DOI: 10.1128/JCM.00731-10
PMCID: PMC3008448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groove binder probe and peptide nucleic acids.PMID 20926703Read ↗

Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.Semantic proximity Read ↗

Quantification of lamivudine-resistant hepatitis B virus mutants by type-specific TaqMan minor groove binder probe assay in patients with chronic hepatitis B.Semantic proximity Read ↗

Dual-probe assay for detection of lamivudine-resistance hepatitis B virus by real-time PCR.Semantic proximity Read ↗

Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes.Semantic proximity Read ↗

Sensitive method for identification of minor hepatitis B mutant viruses.Semantic proximity Read ↗

Real-time PCR detection of multiple lamivudine-resistant mutations with displacing probes in a single tube.Semantic proximity Read ↗

Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing.Semantic proximity Read ↗

Ultrasensitive quantification of hepatitis B virus A1762T/G1764A mutant by a SimpleProbe PCR using a wild-type-selective PCR blocker and a primer-blocker-probe partial-overlap approach.Semantic proximity Read ↗

Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.Semantic proximity Read ↗

A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations.Semantic proximity Read ↗

Rapid quantitation of lamivudine-resistant mutants in lamivudine treated and untreated patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Two Sensitive PCR-Based Methods for Detection of Hepatitis B Virus Variants Associated with Reduced Susceptibility to LamivudineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.