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Article

Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?

Biochimica et biophysica acta - 25 Nov 2005

Pretlow Theresa P, Pretlow Thomas G

Abstract excerpt

Since aberrant crypt foci (ACF) were first described in 1987, they have been the subjects of hundreds of papers; however, the debate continues about their role in colorectal tumorigenesis. This review focuses on the many phenotypic, genetic and epigenetic alterations in ACF that support the hypothesis that ACF are putative precursors of colorectal cancer in both humans and experimental animals. Human ACF, both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16219426
DOI: 10.1016/j.bbcan.2005.06.002

Genes

KRAS
APC
SFRP1
SFRP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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