Article
Mice expressing activated PI3K rapidly develop advanced colon cancer.
Cancer research - 15 Jun 2012
Leystra Alyssa A, Deming Dustin A, Zahm Christopher D, Farhoud Mohammed, Olson Terrah J Paul, Hadac Jamie N, Nettekoven Laura A, Albrecht Dawn M, Clipson Linda, Sullivan Ruth, Washington Mary Kay, Torrealba Jose R, Weichert Jamey P, Halberg Richard B
Abstract excerpt
Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway play a key role in the pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation, and apoptosis. Mutations in the catalytic domain of PI3K that generate a dominantly active kinase are commonly found in human colorectal cancers and have been thought to drive tumor progression but not initiation. However, the effects...
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