Article
Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
Molecular cancer research : MCR - 1 Jun 2012
Parikh Neha, Shuck Ryan L, Nguyen Thuy-Ai, Herron Alan, Donehower Lawrence A
Abstract excerpt
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pancreas, and colon. It remains unclear why some tissues are more susceptible to Ras-induced transformation than others. Here, we globally activated a mutant oncogenic K-Ras allele (K-Ras(G12D)) in mice and examined the tissue-specific effects of this activation on cancer pathobiology, Ras signaling, tumor suppressor,...
Topics
- Active Transport, Cell Nucleus
- Animals
- Antineoplastic Agents, Hormonal
- Blotting, Western
- Cell Nucleus
- Cell Transformation, Neoplastic
- Disease Progression
- Humans
- Mice
- Mice, 129 Strain