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Article

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.

The Journal of cell biology - 11 Feb 2008

D'Andrea Daniela, Liguori Giovanna L, Le Good J Ann, Lonardo Enza, Andersson Olov, Constam Daniel B, Persico Maria G, Minchiotti Gabriella

Abstract excerpt

The EGF-CFC gene cripto governs anterior-posterior (A-P) axis specification in the vertebrate embryo. Existing models suggest that Cripto facilitates binding of Nodal to an ActRII-activin-like kinase (ALK) 4 receptor complex. Cripto also has a crucial function in cellular transformation that is independent of Nodal and ALK4. However, how ALK4-independent Cripto pathways function in vivo has remained unclear. We...

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Source

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Identifiers

PMID: 18268105
DOI: 10.1083/jcb.200709090
PMCID: PMC2234230

Genes

ALK
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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