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Cripto-1: An Embryonic Gene That Promotes Tumorigenesis

13 Jul 2010

Abstract excerpt

Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF-beta ligand Nodal is a key regulator of embryonic development and is a...

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PMID: 20624125
DOI: 10.2217/fon.10.68

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