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Article

Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype.

PloS one - 16 Jan 2008

Pézeron Guillaume, Lambert Guillaume, Dickmeis Thomas, Strähle Uwe, Rosa Frédéric M, Mourrain Philippe

Abstract excerpt

The EGF-CFC factor Oep/Cripto1/Frl1 has been implicated in embryogenesis and several human cancers. During vertebrate development, Oep/Cripto1/Frl1 has been shown to act as an essential coreceptor in the TGFbeta/Nodal pathway, which is crucial for germ layer formation. Although studies in cell cultures suggest that Oep/Cripto1/Frl1 is also implicated in other pathways, in vivo it is solely regarded as a Nodal...

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Identifiers

PMID: 18197245
DOI: 10.1371/journal.pone.0001434
PMCID: PMC2186344

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype.PMID 18197245Read ↗

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.Semantic proximity Read ↗

Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation.Semantic proximity Read ↗

Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling.Semantic proximity Read ↗

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.Semantic proximity Read ↗

Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.Semantic proximity Read ↗

Nodal signaling and the zebrafish organizer.Semantic proximity Read ↗

Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis.Semantic proximity Read ↗

One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling.Semantic proximity Read ↗

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.Semantic proximity Read ↗

Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling.Semantic proximity Read ↗

The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail.Semantic proximity Read ↗

Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade.Semantic proximity Read ↗

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