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Article

Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis.

Development (Cambridge, England) - 1 Dec 2005

Chu Jianhua, Ding Jixiang, Jeays-Ward Katherine, Price Sandy M, Placzek Marysia, Shen Michael M

Abstract excerpt

Several membrane-associated proteins are known to modulate the activity and range of potent morphogenetic signals during development. In particular, members of the EGF-CFC family encode glycosyl-phosphatidylinositol (GPI)-linked proteins that are essential for activity of the transforming growth factor beta (TGFbeta) ligand Nodal, a factor that plays a central role in establishing the vertebrate body plan....

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Source

Identifiers

PMID: 16291788
DOI: 10.1242/dev.02157

Genes

EGF
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis.PMID 16291788Read ↗

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The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.Semantic proximity Read ↗

Cripto localizes Nodal at the limiting membrane of early endosomes.Semantic proximity Read ↗

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.Semantic proximity Read ↗

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.Semantic proximity Read ↗

Cripto-1: An Embryonic Gene That Promotes TumorigenesisSemantic proximity Read ↗

Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.Semantic proximity Read ↗

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