Article
Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.
Developmental biology - 1 Jul 2001
Kimura C, Shen M M, Takeda N, Aizawa S, Matsuo I
Abstract excerpt
The development of the mammalian antero-posterior (A-P) axis is proposed to be established by distinct anterior and posterior signaling centers, anterior visceral endoderm and primitive streak, respectively. Knock-out studies in mice have shown that Otx2 and Cripto have crucial roles in the generation and/or functions of these anterior and posterior centers, respectively. In both Otx2 and Cripto single mutants,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.