Article
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Development (Cambridge, England) - 1 Dec 2003
Morkel Markus, Huelsken Joerg, Wakamiya Maki, Ding Jixiang, van de Wetering Marc, Clevers Hans, Taketo Makoto M, Behringer Richard R, Shen Michael M, Birchmeier Walter
Abstract excerpt
Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.