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Article

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.

Cell - 2 Apr 1999

Gritsman K, Zhang J, Cheng S, Heckscher E, Talbot W S, Schier A F

Abstract excerpt

The zebrafish EGF-CFC gene one-eyed pinhead (oep) is required zygotically for the formation of the ventral neuroectoderm, endoderm, and prechordal plate. Here we report that embryos lacking both maternal and zygotic Oep activity are defective in germ layer formation, organizer development, and the positioning of the anterior-posterior axis. An identical phenotype is displayed by double mutants for the...

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Identifiers

PMID: 10199408
DOI: 10.1016/s0092-8674(00)80720-5

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.PMID 10199408Read ↗

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