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Article

Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.

The Journal of cell biology - 27 Oct 2003

Parisi Silvia, D'Andrea Daniela, Lago Carmine T, Adamson Eileen D, Persico M Graziella, Minchiotti Gabriella

Abstract excerpt

The molecular mechanisms controlling inductive events leading to the specification and terminal differentiation of cardiomyocytes are still largely unknown. We have investigated the role of Cripto, an EGF-CFC factor, in the earliest stages of cardiomyogenesis. We find that both the timing of initiation and the duration of Cripto signaling are crucial for priming differentiation of embryonic stem (ES) cells into...

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Identifiers

PMID: 14581455
DOI: 10.1083/jcb.200303010
PMCID: PMC2173524

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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