Article
Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 12 Feb 2008
Zhang Su-Jiang, Ma Li-Yuan, Huang Qiu-Hua, Li Guo, Gu Bai-Wei, Gao Xiao-Dong, Shi Jing-Yi, Wang Yue-Ying, Gao Li, Cai Xun, Ren Rui-Bao, Zhu Jiang, Chen Zhu, Chen Sai-Juan
Abstract excerpt
Acquisition of additional genetic and/or epigenetic abnormalities other than the BCR/ABL fusion gene is believed to cause disease progression in chronic myeloid leukemia (CML) from chronic phase to blast crisis (BC). To gain insights into the underlying mechanisms of progression to BC, we screened DNA samples from CML patients during blast transformation for mutations in a number of transcription factor genes...
Topics
- Animals
- Base Sequence
- COS Cells
- Cell Line
- Chlorocebus aethiops
- DNA Primers
- Disease Progression
- GATA2 Transcription Factor
- Humans
- Immunoprecipitation