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Article

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.

Blood - 7 May 2009

Miyazaki Kazuko, Yamasaki Norimasa, Oda Hideaki, Kuwata Takeshi, Kanno Yohei, Miyazaki Masaki, Komeno Yukiko, Kitaura Jiro, Honda Zen-ichiro, Warming Søren, Jenkins Nancy A, Copeland Neal G, Kitamura Toshio, Nakamura Takuro, Honda Hiroaki

Abstract excerpt

Chronic myelogenous leukemia (CML) is a hematopoietic disorder originating from p210BCR/ABL-transformed stem cells, which begins as indolent chronic phase (CP) but progresses into fatal blast crisis (BC). To investigate molecular mechanism(s) underlying disease evolution, CML-exhibiting p210BCR/ABL transgenic mice were crossed with BXH2 mice that transmit a replication-competent retrovirus. Whereas nontransgenic...

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Identifiers

PMID: 19234145
DOI: 10.1182/blood-2007-05-088724

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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