Insertional mutagenesis and transformation of hematopoietic stem cells.

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Article

Insertional mutagenesis and transformation of hematopoietic stem cells.

Progress in clinical and biological research - 1 Jan 1990

Ihle J N, Morishita K, Matsugi T, Bartholomew C

Abstract excerpt

The mechanisms that are involved in the control of the normal differentiation of hematopoietic progenitor cells are largely unknown. Moreover, little is known concerning the types of genes that can alter the ability of hematopoietic progenitors to differentiate and cause transformation. One approach to the latter has been to use retroviral induced IL-3-dependent myeloid leukemia cell lines to identify...

Topics

Acute Disease
Animals
Cell Differentiation
Cell Transformation, Viral
Chromosomes, Human, Pair 3
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Hematopoietic Stem Cells
Humans
Interleukin-3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia Virus, Murine

Leukemia, Myeloid

MDS1 and EVI1 Complex Locus Protein

Mice

Mutation

Neoplasm Proteins

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 2169632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2169632-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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