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Article

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia.

The international journal of biochemistry & cell biology - 1 Mar 2012

Rodrigues Neil P, Tipping Alex J, Wang Zhengke, Enver Tariq

Abstract excerpt

Unremitting blood cell production throughout the lifetime of an organism is reliant on hematopoietic stem cells (HSCs). A rare and relatively quiescent cell type, HSCs are, on entry into cell cycle fated to self-renew, undergo apoptosis or differentiate to progenitors (HPCs) that eventually yield specific classes of blood cells. Disruption of these HSC fate decisions is considered to be fundamental to the...

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Identifiers

PMID: 22192845
DOI: 10.1016/j.biocel.2011.12.004
PMCID: PMC3319732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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