Article
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia.
Leukemia - 1 Jan 2017
Ping N, Sun A, Song Y, Wang Q, Yin J, Cheng W, Xu Y, Wen L, Yao H, Ma L, Qiu H, Ruan C, Wu D, Chen S
Abstract excerpt
Acute erythroid leukemia (AEL), characterized by a predominant erythroid proliferation, is a subtype of acute myelogenous leukemia. The genetic basis of AEL remains poorly defined. Through whole-exome sequencing, we identified high frequencies of mutations in CEBPA (32.7%), GATA2 (22.4%), NPM1 (15.5%), SETBP1 (12.1%) and U2AF1 (12.1%). Structure prediction analysis revealed that most of the GATA2 mutations were...
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