Article
Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes.
Leukemia - 1 Jan 2018
Chong C-E, Venugopal P, Stokes P H, Lee Y K, Brautigan P J, Yeung D T O, Babic M, Engler G A, Lane S W, Klingler-Hoffmann M, Matthews J M, D'Andrea R J, Brown A L, Hahn C N, Scott H S
Abstract excerpt
Heterozygous GATA2 mutations underlie an array of complex hematopoietic and lymphatic diseases. Analysis of the literature reporting three recurrent GATA2 germline (g) mutations (gT354M, gR396Q and gR398W) revealed different phenotype tendencies. Although all three mutants differentially predispose to myeloid malignancies, there was no difference in leukemia-free survival for GATA2 patients. Despite intense...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.