Article
Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model.
Cell death & disease - 2 Jun 2021
Fu Ya-Kai, Tan Yun, Wu Bo, Dai Yu-Ting, Xu Xiao-Guang, Pan Meng-Meng, Chen Zhi-Wei, Qiao Niu, Wu Jing, Jiang Lu, Lu Jing, Chen Bing, Rein Avigail, Izraeli Shai, Sun Xiao-Jian, Huang Jin-Yan, Huang Qiu-Hua, Chen Zhu, Chen Sai-Juan
Abstract excerpt
GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies. How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored. Here, we report that Gata2-L359V mutation impeded hematopoietic differentiation in murine embryonic and adult hematopoiesis and blocked murine chronic myeloid leukemia (CML) cell differentiation. We...
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