Article
Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation.
Experimental hematology - 1 Apr 2022
Redondo Monte Enric, Leubolt Georg, Windisch Roland, Kerbs Paul, Dutta Sayantanee, Landspersky Theresa, Istvánffy Rouzanna, Oostendorp Robert A J, Chen-Wichmann Linping, Herold Tobias, Cusan Monica, Schotta Gunnar, Wichmann Christian, Greif Philipp A
Abstract excerpt
GATA2 zinc-finger (ZF) mutations are associated with distinct entities of myeloid malignancies. The specific distribution of these mutations points toward different mechanisms of leukemogenesis depending on the ZF domain affected. In this study, we compared recurring somatic mutations in ZF1 and ZF2. All tested ZF mutants disrupted DNA binding in vitro. In transcription assays, co-expression of FOG1 counteracted...
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