GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.

doi:10.1182/blood-2012-01-403220

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Article

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.

Blood - 12 Jul 2012

Greif Philipp A, Dufour Annika, Konstandin Nikola P, Ksienzyk Bianka, Zellmeier Evelyn, Tizazu Belay, Sturm Jutta, Benthaus Tobias, Herold Tobias, Yaghmaie Marjan, Dörge Petra, Hopfner Karl-Peter, Hauser Andreas, Graf Alexander, Krebs Stefan, Blum Helmut, Kakadia Purvi M, Schneider Stephanie, Hoster Eva, Schneider Friederike, Stanulla Martin, Braess Jan, Sauerland Maria Cristina, Berdel Wolfgang E, Büchner Thomas, Woermann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten, Bohlander Stefan K

Abstract excerpt

Cytogenetically normal acute myeloid leukemia (CN-AML) with biallelic CEBPA gene mutations (biCEPBA) represents a distinct disease entity with a favorable clinical outcome. So far, it is not known whether other genetic alterations cooperate with biCEBPA mutations during leukemogenesis. To identify additional mutations, we performed whole exome sequencing of 5 biCEBPA patients and detected somatic GATA2 zinc...

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PMID: 22649106
DOI: 10.1182/blood-2012-01-403220

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GATA2

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