Article
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
Archives of general psychiatry - 1 Feb 2008
Bradley Rebekah G, Binder Elisabeth B, Epstein Michael P, Tang Yilang, Nair Hemu P, Liu Wei, Gillespie Charles F, Berg Tiina, Evces Mark, Newport D Jeffrey, Stowe Zachary N, Heim Christine M, Nemeroff Charles B, Schwartz Ann, Cubells Joseph F, Ressler Kerry J
Abstract excerpt
CONTEXT: Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression. OBJECTIVE: To examine whether the effects of child abuse on adult...
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