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Article

Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.

Biological psychiatry - 1 Oct 2009

Tyrka Audrey R, Price Lawrence H, Gelernter Joel, Schepker Caroline, Anderson George M, Carpenter Linda L

Abstract excerpt

BACKGROUND: Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression. This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress. METHODS: One hundred...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19596121
DOI: 10.1016/j.biopsych.2009.05.012
PMCID: PMC2881567

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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