Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population.

doi:10.1002/ajmg.b.31131

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2010

Grabe Hans Jörgen, Schwahn Christian, Appel Katja, Mahler Jessie, Schulz Andrea, Spitzer Carsten, Fenske Kristin, Barnow Sven, Lucht Michael, Freyberger Harald Jürgen, John Ulrich, Teumer Alexander, Wallaschofski Henri, Nauck Matthias, Völzke Henry

Abstract excerpt

Dysregulations of the hypothalamic-pituitary-adrenal (HPA) axis have been implicated in the pathogenesis of depressive disorders and the corticotropin-releasing hormone (CRH) was found to modulate emotional memory consolidation. Recently, two studies have reported an interaction between childhood abuse and the TAT-haplotype of the CRH-Receptor Gene (CRHR1) connecting childhood adversities and genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child Abuse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRF Receptor, Type 1

Share to Depressive Disorder, Major

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Psychological Tests

Share to Receptors, Corticotropin-Releasing Hormone

Share to Stress, Psychological

Source

Open in PubMed

Identifiers

PMID: 20957648
DOI: 10.1002/ajmg.b.31131

Genes

CRHR1
TAT
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population.PMID 20957648Read ↗

Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.Semantic proximity Read ↗

Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study.Semantic proximity Read ↗

Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.Semantic proximity Read ↗

Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.Semantic proximity Read ↗

Interactions of childhood maltreatment and genetic variations in adult depression: A systematic review.Semantic proximity Read ↗

Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.Semantic proximity Read ↗

A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women.Semantic proximity Read ↗

Influence of genetic polymorphisms involved in the hypothalamic-pituitary-adrenal axis and their interactions with environmental factors on antidepressant response.Semantic proximity Read ↗

Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population.Semantic proximity Read ↗

Interaction between COMT Val158 Met polymorphism and childhood trauma predicts risk for depression in men.Semantic proximity Read ↗

Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and DepressionSemantic proximity Read ↗

HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.