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Article

A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2011

Kranzler Henry R, Feinn Richard, Nelson Elliot C, Covault Jonathan, Anton Raymond F, Farrer Lindsay, Gelernter Joel

Abstract excerpt

Adverse childhood experiences (ACEs) increase the risk for adult depression and substance dependence, possibly mediated by the corticotropin-releasing hormone type 1 receptor (CRHR1). In some studies, a three-SNP "T-A-T" haplotype in CRHR1, which encodes CRHR1, exerted a protective moderating effect on risk of depression in adults with ACEs. Other studies have shown a main or moderating effect of SNPs in CRHR1 on...

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Source

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Identifiers

PMID: 21998007
DOI: 10.1002/ajmg.b.31243
PMCID: PMC3227028

Genes

CRHR1
TAT
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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