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Article

Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2010

Ressler Kerry J, Bradley Bekh, Mercer Kristina B, Deveau Todd C, Smith Alicia K, Gillespie Charles F, Nemeroff Charles B, Cubells Joseph F, Binder Elisabeth B

Abstract excerpt

Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems. Our objective was to examine whether the effects of child abuse are moderated by gene x gene (...

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Source

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Identifiers

PMID: 20029939
DOI: 10.1002/ajmg.b.31052
PMCID: PMC2924813

Genes

CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20029939-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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