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Article

Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

Archives of general psychiatry - 1 Sept 2009

Polanczyk Guilherme, Caspi Avshalom, Williams Benjamin, Price Thomas S, Danese Andrea, Sugden Karen, Uher Rudolf, Poulton Richie, Moffitt Terrie E

Abstract excerpt

CONTEXT: A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). OBJECTIVE: To replicate the interaction between childhood maltreatment and a TAT haplotype...

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Source

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Identifiers

PMID: 19736354
DOI: 10.1001/archgenpsychiatry.2009.114
PMCID: PMC3750953

Genes

CRHR1
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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