Article
An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29.
Genes and immunity - 1 Mar 2008
Shugart Y Y, Silverberg M S, Duerr R H, Taylor K D, Wang M-H, Zarfas K, Schumm L P, Bromfield G, Steinhart A H, Griffiths A M, Kane S V, Barmada M M, Rotter J I, Mei L, Bernstein C N, Bayless T M, Langelier D, Cohen A, Bitton A, Rioux J D, Cho J H, Brant S R
Abstract excerpt
Inflammatory bowel disease (IBD) is a complex genetic disorder of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC), with increased risk in Ashkenazi Jews. Twelve genome-wide linkage screens have identified multiple loci, but these screens have been of modest size and have used low-density microsatellite markers. We, therefore, performed a high-density single-nucleotide polymorphism (SNP)...
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