Article
Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease.
Human genetics - 1 Sept 2018
Schiff E R, Frampton M, Ben-Yosef N, Avila B E, Semplici F, Pontikos N, Bloom S L, McCartney S A, Vega R, Lovat L B, Wood E, Hart A, Israeli E, Crespi D, Furman M A, Mann S, Murray C D, Segal A W, Levine A P
Abstract excerpt
Rare variants are thought to contribute to the genetics of inflammatory bowel disease (IBD), which is more common amongst the Ashkenazi Jewish (AJ) population. A family-based approach using exome sequencing of AJ individuals with IBD was employed with a view to identify novel rare genetic variants for this disease. Exome sequencing was performed on 960 Jewish individuals including 513 from 199 multiplex families...
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