Article
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
PLoS genetics - 1 Jan 2012
Kenny Eimear E, Pe'er Itsik, Karban Amir, Ozelius Laurie, Mitchell Adele A, Ng Sok Meng, Erazo Monica, Ostrer Harry, Abraham Clara, Abreu Maria T, Atzmon Gil, Barzilai Nir, Brant Steven R, Bressman Susan, Burns Edward R, Chowers Yehuda, Clark Lorraine N, Darvasi Ariel, Doheny Dana, Duerr Richard H, Eliakim Rami, Giladi Nir, Gregersen Peter K, Hakonarson Hakon, Jones Michelle R, Marder Karen, McGovern Dermot P B, Mulle Jennifer, Orr-Urtreger Avi, Proctor Deborah D, Pulver Ann, Rotter Jerome I, Silverberg Mark S, Ullman Thomas, Warren Stephen T, Waterman Matti, Zhang Wei, Bergman Aviv, Mayer Lloyd, Katz Seymour, Desnick Robert J, Cho Judy H, Peter Inga
Abstract excerpt
Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with the host immune system in genetically susceptible individuals. The largest meta-analysis of genome-wide association to date identified 71 CD-susceptibility loci in individuals of European ancestry. An important epidemiological feature of CD is that it is 2-4 times more prevalent among individuals of Ashkenazi...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.