Article
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998
Cho J H, Nicolae D L, Gold L H, Fields C T, LaBuda M C, Rohal P M, Pickles M R, Qin L, Fu Y, Mann J S, Kirschner B S, Jabs E W, Weber J, Hanauer S B, Bayless T M, Brant S R
Abstract excerpt
The idiopathic inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin concordance, and ethnic differences in familial risks have established that CD and UC are complex, non-Mendelian, related genetic disorders. We performed a genome-wide screen using 377 autosomal markers, on 297 CD, UC, or mixed...
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