Article
A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population.
Human genetics - 1 Feb 2021
Streicher Samantha A, Klein Alison P, Olson Sara H, Kurtz Robert C, Amundadottir Laufey T, DeWan Andrew T, Zhao Hongyu, Risch Harvey A
Abstract excerpt
Jews are estimated to be at increased risk of pancreatic cancer compared to non-Jews, but their observed 50-80% excess risk is not explained by known non-genetic or genetic risk factors. We conducted a GWAS in a case-control sample of American Jews, largely Ashkenazi, including 406 pancreatic cancer patients and 2332 controls, identified in the dbGaP, PanScan I/II, PanC4 and GERA data sets. We then examined...
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