Article
A genome-wide search identifies potential new susceptibility loci for Crohn's disease.
Inflammatory bowel diseases - 1 Nov 1999
Ma Y, Ohmen J D, Li Z, Bentley L G, McElree C, Pressman S, Targan S R, Fischel-Ghodsian N, Rotter J I, Yang H
Abstract excerpt
Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susceptibility loci on chromosome 16 (IBD1 for CD), and on chromosomes 1, 3, 4, 6, 7, 10, and 12 for...
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