Article
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci.
American journal of human genetics - 1 Jun 2000
Rioux J D, Silverberg M S, Daly M J, Steinhart A H, McLeod R S, Griffiths A M, Green T, Brettin T S, Stone V, Bull S B, Bitton A, Williams C N, Greenberg G R, Cohen Z, Lander E S, Hudson T J, Siminovitch K A
Abstract excerpt
The chronic inflammatory bowel diseases (IBDs)-Crohn disease (CD) and ulcerative colitis (UC)-are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions have a peak incidence in early adulthood and a combined prevalence of approximately 100-200/100,000. Although the etiology of IBD is multifactorial, a significant genetic contribution to disease susceptibility is implied by...
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