Article

A missense variant effect map for the human tumour suppressor protein CHK2

2024-02-15

Abstract excerpt

The tumour suppressor CHEK2 encodes the serine/threonine protein kinase CHK2 which, upon DNA damage, is important for pausing the cell cycle, initiating DNA repair and inducing apoptosis. CHK2 phosphorylation of the tumour suppressor BRCA1 is also important for mitotic spindle assembly and chromosomal stability. Consistent with its cell cycle checkpoint role, both germline and somatic variants in CHEK2 have been...

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Literature Corpus work: 9e2a192a-9511-52fe-be1f-e0aab67e74b2
DOI: 10.1101/2024.02.13.579700

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