The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

doi:10.1101/gad.8.20.2401

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Article

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

Genes & development - 15 Oct 1994

Allen J B, Zhou Z, Siede W, Friedberg E C, Elledge S J

Abstract excerpt

Inhibition of DNA synthesis prevents mitotic entry through the action of the S-phase checkpoint. We have isolated S-phase arrest-defective (sad) mutants that show lethality in the presence of the DNA synthesis inhibitor hydroxyurea (HU). Several of these mutants show phenotypes consistent with inappropriate mitotic entry in the presence of unreplicated DNA, indicating a defect in the S-phase checkpoint. sad1...

Topics

Base Sequence
Cell Cycle
Cloning, Molecular
DNA Damage
DNA Primers
DNA Replication
DNA, Fungal
Feedback
Gene Expression Regulation, Fungal
Genes, Fungal
Hydroxyurea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Molecular Sequence Data

Mutation

Protein Kinases

Saccharomyces cerevisiae

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7958905
DOI: 10.1101/gad.8.20.2401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7958905-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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