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Article

Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Cell reports - 12 Sept 2017

Pai Chen-Chun, Kishkevich Anastasiya, Deegan Rachel S, Keszthelyi Andrea, Folkes Lisa, Kearsey Stephen E, De León Nagore, Soriano Ignacio, de Bruin Robertus Antonius Maria, Carr Antony M, Humphrey Timothy C

Abstract excerpt

Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress and DNA damage through promoting MluI cell-cycle box (MCB) binding factor (MBF)-complex-dependent transcription in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28903048
DOI: 10.1016/j.celrep.2017.08.058
PMCID: PMC5608972

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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