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Article

Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients.

Pharmacogenomics - 1 Jul 2007

Nakai Kenji, Tsuboi Jyunichi, Okabayashi Hitoshi, Fukuhiro Yoshiaki, Oka Takanori, Habano Wataru, Fukushima Noriko, Nakai Keiko, Obara Wataru, Fujioka Tomoaki, Suwabe Akira, Gurwitz David

Abstract excerpt

OBJECTIVES: Vitamin K epoxide reductase (VKORC1) is the drug target for inhibition by coumarin-based anticoagulant drugs such as warfarin. Warfarin therapy has been reported as a leading cause of drug-related hospitalization and there is therefore an urgent need to develop tests for better warfarin prescription. We report here the distribution of the intron 1 -136 T>C (1173 T>C intron) polymorphism of VKORC1,...

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Source

Identifiers

PMID: 18240904
DOI: 10.2217/14622416.8.7.713

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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