Article
Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans.
Pharmacogenetics and genomics - 1 Feb 2006
Takahashi Harumi, Wilkinson Grant R, Nutescu Edith A, Morita Takashi, Ritchie Marylyn D, Scordo Maria G, Pengo Vittorio, Barban Martina, Padrini Roberto, Ieiri Ichiro, Otsubo Kenji, Kashima Toshitaka, Kimura Sosuke, Kijima Shinichi, Echizen Hirotoshi
Abstract excerpt
OBJECTIVE: To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses needed to achieve anticoagulation, in particular the possible involvement of genetic variability in vitamin K epoxide reductase (VKOR) and CYP2C9. METHODS: Warfarin maintenance dose, unbound plasma S-warfarin concentration [Cu(S)] and INR were determined in 157 Caucasians, 172 Japanese,...
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