Article
Contribution of 1173C > T polymorphism in the VKORC1 gene to warfarin dose requirements in Han Chinese patients receiving anticoagulation.
International journal of clinical pharmacology and therapeutics - 1 Jan 2011
Yang J, Huang C, Shen Z, Miao L
Abstract excerpt
OBJECTIVE: The objective was to assess 1173C > T polymorphism of the VKORC1 gene and its contribution to warfarin dose requirements in Han Chinese patients. METHODS: Blood samples were collected from 178 patients with stable warfarin dose requirements and an international normalized ratio (INR) of the prothrombin time within the target range (1.5 - 3.0). Polymorphisms for VKORC1 (1173C > T), CYP2C9, venous INR,...
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