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Article

Defects in somite formation in lunatic fringe-deficient mice.

Nature - 23 Jul 1998

Zhang N, Gridley T

Abstract excerpt

Segmentation in vertebrates first arises when the unsegmented paraxial mesoderm subdivides to form paired epithelial spheres called somites. The Notch signalling pathway is important in regulating the formation and anterior-posterior patterning of the vertebrate somite. One component of the Notch signalling pathway in Drosophila is the fringe gene, which encodes a secreted signalling molecule required for...

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PMID: 9690472
DOI: 10.1038/28625

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in somite formation in lunatic fringe-deficient mice.PMID 9690472Read ↗

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.Semantic proximity Read ↗

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.Semantic proximity Read ↗

Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.Semantic proximity Read ↗

Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton.Semantic proximity Read ↗

Lunatic fringe promotes the lateral inhibition of neurogenesis.Semantic proximity Read ↗

Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.Semantic proximity Read ↗

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.Semantic proximity Read ↗

Dynamic expression and essential functions of Hes7 in somite segmentation.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.Semantic proximity Read ↗

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