Defects in somite formation in lunatic fringe-deficient mice.

doi:10.1038/28625

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Article

Defects in somite formation in lunatic fringe-deficient mice.

Nature - 23 Jul 1998

Zhang N, Gridley T

Abstract excerpt

Segmentation in vertebrates first arises when the unsegmented paraxial mesoderm subdivides to form paired epithelial spheres called somites. The Notch signalling pathway is important in regulating the formation and anterior-posterior patterning of the vertebrate somite. One component of the Notch...

Topics

Animals
Body Patterning
Cell Lineage
Embryonic and Fetal Development
Fetus
Gene Expression Regulation, Developmental
Gene Targeting
Genetic Markers
Glycosyltransferases
Ligands
Mice
Phenotype
Proteins
Signal Transduction
Somites

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