Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous targeted exchange of two nucleotides by single-stranded oligonucleotides clusters within a region of about fourteen nucleotides.

BMC molecular biology - 28 Jan 2008

Hegele Heike, Wuepping Matthias, Ref Caroline, Kenner Oliver, Kaufmann Dieter

Abstract excerpt

BACKGROUND: Transfection of cells with gene-specific, single-stranded oligonucleotides can induce the targeted exchange of one or two nucleotides in the targeted gene. To characterize the features of the DNA-repair mechanisms involved, we examined the maximal distance for the simultaneous exchange of two nucleotides by a single-stranded oligonucleotide. The chosen experimental system was the correction of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cricetinae
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to DNA Repair

Share to DNA, Single-Stranded

Share to Hypoxanthine Phosphoribosyltransferase

Share to Oligodeoxyribonucleotides

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 18226192
DOI: 10.1186/1471-2199-9-14
PMCID: PMC2266939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous targeted exchange of two nucleotides by single-stranded oligonucleotides clusters within a region of about fourteen nucleotides.PMID 18226192Read ↗

Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells.Semantic proximity Read ↗

Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.Semantic proximity Read ↗

Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system.Semantic proximity Read ↗

Triplex-forming oligonucleotide target sequences in the human genome.Semantic proximity Read ↗

Marking of specific sequences in double-stranded DNA molecules--SNP detection and direct observation.Semantic proximity Read ↗

Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides.Semantic proximity Read ↗

Stimulation of D-loop formation by polypurine/polypyrimidine sequences.Semantic proximity Read ↗

Mutagenic properties of a unique abasic site in mammalian cells.Semantic proximity Read ↗

Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents.Semantic proximity Read ↗

DNA pairing is an important step in the process of targeted nucleotide exchange.Semantic proximity Read ↗

Sequence analysis of deletion mutations at the HPRT locus of human T-lymphocytes: association of a palindromic structure with a breakpoint cluster in exon 2.Semantic proximity Read ↗

DNA-DNA hybridization of single-copy DNA sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.