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Article

Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells.

Oligonucleotides - 1 Jan 2008

Wang Zai, Zhou Zhong-Jun, Liu De-Pei, Huang Jian-Dong

Abstract excerpt

Single-stranded oligonucleotide (SSO)-mediated gene modification is a newly developed tool for site-specific gene repair in mammalian cells; however, the corrected cells always show G2/M arrest and cannot divide to form colonies. This phenomenon and the unclear mechanism seriously challenge the future application of this technique. In this study, we developed an efficient SSO-mediated DNA repair system based on...

Read the complete abstract on PubMed

Topics

Alleles
Ataxia Telangiectasia Mutated Proteins
Base Sequence
Cell Cycle Proteins
Cell Line
DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Primers

DNA Repair

DNA-Binding Proteins

Flow Cytometry

Humans

Oligonucleotides

Protein Serine-Threonine Kinases

RNA, Small Interfering

Tumor Suppressor Proteins

Source

Identifiers

PMID: 18321160
DOI: 10.1089/oli.2007.0093

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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