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Article

Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system.

Biochemical and biophysical research communications - 9 Sept 2005

Yin Wen-Xuan, Wu Xue-Song, Liu Guang, Li Zhu-Hong, Watt Rory M, Huang Jian-Dong, Liu De-Pei, Liang Chih-Chuan

Abstract excerpt

Synthetic oligonucleotides had been employed in DNA repair and promised great potentials in gene therapy. To test the ability of single-stranded oligonucleotide (SSO)-mediated gene repair within a chromosomal site in human cells, a HeLa cell line stably integrated with mutant enhanced green fluorescence protein gene (mEGFP) in the genome was established. Transfection with specific SSOs successfully repaired the...

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Identifiers

PMID: 16039616
DOI: 10.1016/j.bbrc.2005.06.193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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