Article
DNA pairing is an important step in the process of targeted nucleotide exchange.
Nucleic acids research - 1 Feb 2003
Drury Miya D, Kmiec Eric B
Abstract excerpt
Modified single-stranded DNA oligonucleotides can direct the repair of genetic mutations in yeast, plant and mammalian cells. The mechanism by which these molecules exert their effect is being elucidated, but the first phase is likely to involve the homologous alignment of the single strand with its complementary sequence in the target gene. In this study, we establish the importance of such DNA pairing in...
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