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Article

Stimulation of D-loop formation by polypurine/polypyrimidine sequences.

Nucleic acids research - 1 Feb 2003

Biet Elodie, Sun Jian-Sheng, Dutreix Marie

Abstract excerpt

Most of the approaches used to correct gene mutations in mammalian cells involve the targeting of short nucleotide molecules to homologous chromosomal sequences and the replacement of resident sequences via homologous recombination and mismatch repair. The limited efficiency and inconsistent reproducibility of these techniques are major constraints to their use in gene therapy. One of the main problems is that it...

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Identifiers

PMID: 12560497
DOI: 10.1093/nar/gkg195
PMCID: PMC149215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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