Article
Sequence analysis of deletion mutations at the HPRT locus of human T-lymphocytes: association of a palindromic structure with a breakpoint cluster in exon 2.
Mutagenesis - 1 Sept 1996
Osterholm A M, Bastlová T, Meijer A, Podlutsky A, Zanesi N, Hou S M
Abstract excerpt
To study the structure and mechanism of deletion mutation in human somatic cells in vivo, we have identified and sequenced the breakpoints of 16 independent deletions at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus in human T-lymphocytes. Seven deletions were found in exon 2,...
Topics
- Base Sequence
- Exons
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Molecular Sequence Data
- Multigene Family
- Mutation
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Sequence Deletion