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Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

15 Jan 2008

Abstract excerpt

PURPOSE: Epidermal growth factor receptor variant III (EGFRvIII) is an oncogenic, constitutively active mutant form of the EGFR that is commonly expressed in glioblastoma and is also detected in a number of epithelial cancers. EGFRvIII presents a unique antigenic target for anti-EGFRvIII vaccines and it has been shown to modulate response to EGFR kinase inhibitor therapy. Thus, detection in clinical samples may...

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PMID: 18223223
DOI: 10.1158/1078-0432.ccr-07-1966

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